Essential resurfacing work is due to take place on the A628 Woodhead Pass near Sheffield and Barnsley, Highways England has announced.
Contractors will resurface a 14 mile stretch of the route between the A616 Flouch roundabout and the A57 Gun Inn junction.
The work will take place between 8pm and 6am from 16 November until 19 November.
Features of the project include replacing reflective road studs and repainting road markings.
Highways England project manager Tim Calvert said: "This is essential maintenance work and we need to close the A628 overnight when traffic levels are at their lowest.
"We are aware that there are other roadworks taking place along the diversion route, including the smart motorway scheme between junctions 39 and 42 on the M1.
"It is important that the resurfacing work on the A628 takes place before the winter months so drivers can benefit from smoother journeys."
(LM/CD)
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